Sildenafil can be a potent and selective inhibitor of cGMP-unique phosphodiesterase kind 5 (PDE5), that is responsible for degradation of cGMP from the corpus cavernosum. The molecular construction of sildenafil is analogous to that of cGMP and acts as being a aggressive binding agent of PDE5 inside the corpus cavernosum, resulting in much more cGM

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